Questions · Opioid-Free versus Opioid-Sparing Anesthesia
8 questions, 0 approved. Approve them one at a time — a quiz shows nothing you have not.
Recall — derived from a kept point
You are running a processed EEG monitor during an opioid-free anaesthetic. Describe how the displayed indices and the spectral pattern are expected to differ from what you see during an opioid-based technique.
Answer: Expect the processed EEG indices to read higher during opioid-free anaesthesia: the patient state index and the spectral edge frequency both ran higher in this prospective observational study, and the alpha power typical of an opioid-based technique was absent.
A higher index and missing alpha power during opioid-free anaesthesia is what this technique looks like on the monitor, so read the number against the technique you are actually running.
Source claim: Expect higher processed EEG indices during opioid-free anaesthesia: patient state index and spectral edge frequency ran higher, and the alpha power typical of opioid-based technique was absent.
Anesthesia Depth Monitoring During Opioid Free Anesthesia - A Prospective Observational Study, BMC anesthesiology 2025
recall · CA-2 · phrased by llm
A resident reads the randomised trial of opioid-free anaesthesia in ambulatory total hip arthroplasty and concludes opioid-free anaesthesia has no benefit anywhere. State what that trial compared, what it found for opioid consumption, pain and recovery, and why the conclusion is broader than the evidence.
Answer: The trial compared opioid-free anaesthesia with opioid-sparing anaesthesia in day-case hip arthroplasty and found opioid-free anaesthesia did not reduce 24-hour opioid consumption, with similar pain scores and similar walking recovery. It is a single randomised trial in one ambulatory operation, and the comparator was opioid-sparing anaesthesia rather than a conventional opioid-based technique, so it does not support a general claim about opioid-free anaesthesia in other settings.
This trial answers one question — opioid-free versus opioid-sparing in day-case hip arthroplasty — and the answer there was no difference in 24-hour opioid use, pain, or walking recovery.
Source claim: In day-case hip arthroplasty, opioid-free anaesthesia did not reduce 24-hour opioid consumption compared with opioid-sparing anaesthesia, with similar pain scores and walking recovery.
Opioid-Free Versus Opioid-Sparing Anaesthesia in Ambulatory Total Hip Arthroplasty: A Randomised Controlled Trial, British journal of anaesthesia 2024
recall · CA-3 · phrased by llm
In the network meta-analysis of laparoscopic bariatric surgery comparing opioid-free with opioid-sparing anaesthesia, state the benefit and the cost of going fully opioid-free, and what happened to pain and opioid use.
Answer: Opioid-free anaesthesia reduced nausea and vomiting more than opioid-sparing anaesthesia did, but it roughly doubled the risk of bradycardia, with no difference in pain or opioid use between the two approaches.
In bariatric patients the trade for going fully opioid-free is less nausea and vomiting against roughly double the bradycardia, with pain and opioid use unchanged.
Source claim: In laparoscopic bariatric surgery, opioid-free anaesthesia reduced nausea and vomiting more than opioid-sparing anaesthesia, but roughly doubled the risk of bradycardia with no difference in pain or opioid use.
Opioid-Sparing Anesthesia Versus Opioid-Free Anesthesia for the Prevention of Postoperative Nausea and Vomiting After Laparoscopic Bariatric Surgery: A Systematic Review and Network Meta-Analysis, Anesthesia and analgesia 2025
recall · CA-2 · phrased by llm
In the randomised trial of balanced dexmedetomidine-based opioid-free anaesthesia versus balanced remifentanil-based anaesthesia for major or intermediate noncardiac surgery, why was the trial stopped early, and what happened to the rate of opioid-related adverse events and what drove that change?
Answer: The dexmedetomidine-based opioid-free technique was stopped early after five cases of severe bradycardia. Opioid-related adverse events rose from 67% to 78%, driven by hypoxaemia.
The opioid-free arm was stopped for severe bradycardia and still ended up with more opioid-related adverse events, 67% to 78%, mostly hypoxaemia.
Source claim: A dexmedetomidine-based opioid-free technique was stopped early after five cases of severe bradycardia, and increased opioid-related adverse events from 67% to 78%, driven by hypoxaemia.
Balanced Opioid-Free Anesthesia With Dexmedetomidine Versus Balanced Anesthesia With Remifentanil for Major or Intermediate Noncardiac Surgery, Anesthesiology 2021
recall · CA-1 · phrased by llm
The point with one number taken out. No model wrote any of this: the stem is the sentence you reviewed, minus a digit, and the paper it came from is named beneath it.
Open prompts
How would you teach this to a CA-1 in two minutes?
open · CA-3 · phrased by derived
Where does the evidence for this actually stop?
open · CA-3 · phrased by derived
What would you do differently in a resource-limited setting?
open · CA-3 · phrased by derived
Defend the alternative you decided against.
open · CA-3 · phrased by derived
Questions only — nothing here asserts anything, which is why a model is allowed to phrase them. Where no model was reachable these are the level defaults.