Anesthetic Neurotoxicity in Children

CA-1 · I.C.1.a.1 I.C.1.b.1 I.A.4.d

34Sources
6Kept
0Dropped

1 · Find evidence

PubMed query

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34 candidate papers

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Same-day build

PubMed query

Runs the tiered searches, drafts one point per included paper, runs the citation gate and builds a draft deck — the steps below, unattended. Same-day build — drafted locally (medgemma:27b), confirmed against each abstract. The deck still lands in draft: nothing here approves anything.

2 · Teaching points

Source

A point with no source will not survive the gate. That is the point of the gate.

6 points

Pooling prospectively assessed children, a single general anaesthetic was associated with modestly worse parent-reported behaviour scores while full-scale IQ was unaffected. PMID 33250180 kept
In the GAS randomised trial, just under an hour of sevoflurane anaesthesia in infancy gave a full-scale IQ at age five equivalent to awake-regional anaesthesia, with a difference of 0.23 points. PMID 30782342 kept
Comparing 105 sibling pairs, a single anaesthetic before 36 months left no significant difference in IQ, memory, attention, executive function, language or behaviour in later childhood. PMID 27272582 kept
Studies examining intraoperative blood pressure and later neurocognitive outcome have not found an association, so hypotension is not established as the mediating mechanism. PMID 37552011 kept
Across 31 studies, associations between childhood anaesthesia and neurodevelopment differ by domain — small deficits in executive function, behaviour and academics, with cognition barely affected. PMID 35708687 kept
In the MASK study, general intelligence was unaffected by exposure before age three, but children with multiple exposures showed reduced processing speed and fine motor ability that single-exposure children did not. PMID 29672337 kept

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