Perioperative Intravenous Lidocaine

CA-2 · II.D.3.f.4

24Sources
6Kept
0Dropped

1 · Find evidence

PubMed query

Every result is a real PMID returned by NCBI. Nothing on this step is generated.

Ask OpenEvidence ↗

OpenEvidence opens in your own logged-in session with the question filled in. Nothing is fetched on your behalf — read it there, then add what you want to teach as a point below, citing the source it came from.

24 candidate papers

Ticked papers are the ones a deck may be built from. Unticking one needs a reason — the citation gate proves a paper exists, and nothing but you decides whether it should be taught. A tier badge appears where the paper’s publication type is known.

Same-day build

PubMed query

Runs the tiered searches, drafts one point per included paper, runs the citation gate and builds a draft deck — the steps below, unattended. Same-day build — drafted locally (medgemma:27b), confirmed against each abstract. The deck still lands in draft: nothing here approves anything.

2 · Teaching points

Source

A point with no source will not survive the gate. That is the point of the gate.

6 points

The Cochrane review of 68 trials and 4,525 patients found the evidence for lidocaine on early postoperative pain very low quality, with infusion regimens varying from 1 to 5 mg/kg/h and no consistent stopping point. PMID 29864216 kept
In the ALLEGRO trial, 2% intravenous lidocaine did not improve return of gut function at 72 hours after minimally invasive colon resection (57.3% versus 59.0%) and none of eleven secondary outcomes differed. PMID 39602290 kept
Systemic lidocaine has antinociceptive effects in both acute and chronic pain states, acting via multiple mechanisms beyond sodium channel blockade, including silencing ectopic discharges and suppressing inflammation. PMID 31303268 kept
In abdominal and ambulatory surgery, lidocaine infusion reduced pain and opioid use, brought first flatus up to 23 hours earlier and shortened stay by about 1.1 days, but had no effect in tonsillectomy, hip arthroplasty or coronary bypass. PMID 20518581 kept
Perioperative lidocaine in breast cancer surgery reduced persistent pain at three months from 47.4% to 11.8% and reduced the area of secondary hyperalgesia. PMID 22699129 kept
At commonly recommended doses lidocaine's therapeutic index is very high and plasma concentrations stay well below cardiotoxic and neurotoxic thresholds, which is the basis for judging its benefit-risk against other analgesic strategies. PMID 30117019 kept

Checks every citation against PubMed, the DOI resolver, or a live fetch. Points that do not resolve are dropped and shown to you with the reason — never quietly softened.

4 · Build the deck

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Decks

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5 · Question bank

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