Intraoperative Methadone

CA-3 · II.D.2.c.1 I.A.4.a.3.a I.A.4.c

28Sources
6Kept
0Dropped

1 · Find evidence

PubMed query

Every result is a real PMID returned by NCBI. Nothing on this step is generated.

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OpenEvidence opens in your own logged-in session with the question filled in. Nothing is fetched on your behalf — read it there, then add what you want to teach as a point below, citing the source it came from.

28 candidate papers

Ticked papers are the ones a deck may be built from. Unticking one needs a reason — the citation gate proves a paper exists, and nothing but you decides whether it should be taught. A tier badge appears where the paper’s publication type is known.

Same-day build

PubMed query

Runs the tiered searches, drafts one point per included paper, runs the citation gate and builds a draft deck — the steps below, unattended. Same-day build — drafted locally (medgemma:27b), confirmed against each abstract. The deck still lands in draft: nothing here approves anything.

2 · Teaching points

Source

A point with no source will not survive the gate. That is the point of the gate.

6 points

Pooled across ten studies, methadone reduced 24-hour opioid consumption by about 15 mg oral morphine equivalents and improved analgesia satisfaction, with no difference in nausea, sedation or respiratory depression. PMID 31613867 kept
Across 13 trials, intraoperative methadone lowered pain at rest and on movement at 24, 48 and 72 hours and cut opioid consumption, with sequential analysis indicating no further trials are needed for pain at rest to 48 hours. PMID 31743194 kept
A single 0.2 mg/kg methadone bolus before incision in multilevel spine surgery halved opioid requirement at 48 and 72 hours and halved pain scores at 48 hours versus a sufentanil infusion. PMID 20418538 kept
A single induction dose of intravenous methadone did not prolong the QTc: new QTcF above 500 ms occurred in 2.5% with methadone versus 8.3% without, with no correlation between dose and QTcF. PMID 42399190 kept
Intravenous methadone produces effective postoperative analgesia and lowers opioid consumption without more adverse effects than other opioids, and may have potential to prevent persistent postoperative pain. PMID 37308798 kept
A single intraoperative dose of methadone ≥0.2 mg/kg results in less postoperative pain and opioid consumption compared to short-acting IV opioids in adult cardiac surgery patients. PMID 42085333 kept

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5 · Question bank

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